A fundamental problem in computational algebraic geometry is the computation of the resultant. A central question is when and how to compute it as the determinant of a matrix whose elements are the coefficients of the input polynomials up-to sign. This problem is well understood for unmixed multihomogeneous systems, that is for systems consisting of multihomogeneous polynomials with the same support. However, little is known for mixed systems, that is for systems consisting of polynomials with different supports. We consider the computation of the multihomogeneous resultant of special classes of mixed multilinear systems. We present a constructive approach that expresses the resultant as the exact determinant of a Koszul resultant matrix, that is a matrix constructed from maps in the Koszul complex. We exploit the resultant matrix to propose an algorithm to solve such systems. In the process we extend the classical eigenvalues and eigenvectors criterion to a more general setting. Our extension of the eigenvalues criterion applies to a general class of matrices, including the Sylvester-type and the Koszul-type ones.