Description
Cells communicate with each other by sending extra-cellular ligands such as hormones. The ligands of interest are reproductive hormones which, once recognized by their receptors at the plasma membrane, trigger a signaling cascade within the cell. These receptors are internalized in different compartments called endosomes, which produce a cellular response with a different physiological role. This notion of compartmentalization is mathematically modeled using two approaches: a structured model based on systems of ordinary differential equations, and an individual-centered model using piecewise deterministic Markov processes. This modeling enables us to study the effect of internalization and recycling on the quantity of cellular response. The ultimate aim of the project is to further characterize the pharmacological action of ligands, contributing to a better understanding of gonadotropin signaling pathways.
