Séminaire de Mathématique-Biologie

The role of microRNAs in muscle differentiation

by Prof. Jeremie KROPP (IHÉS)

Amphithéâtre Léon Motchane (IHES)

Amphithéâtre Léon Motchane


Le Bois-Marie 35, route de Chartres 91440 Bures-sur-Yvette
MicroRNAs are recently discovered regulators of gene expression, coordinating many biological processes. They are especially important for developmental processes, including cell differentiation, while their deregulation causes diseases like cancer. In particular, microRNAs are key regulators of muscle differentiation, a complex process necessary for the formation of muscle fibers. I'll describe the regulation of skeletal muscle differentiation by the miR-98 - E2F5 molecular pathway.