35, route de Chartres
MicroRNAs are recently discovered regulators of gene expression, coordinating many biological processes. They are especially important for developmental processes, including cell differentiation, while their deregulation causes diseases like cancer.
In particular, microRNAs are key regulators of muscle differentiation, a complex process necessary for the formation of muscle fibers. I'll describe the regulation of skeletal muscle differentiation by the miR-98 - E2F5 molecular pathway.