Séminaire de Mathématique-Biologie

When slicing meets splicing

by Prof. Annick HAREL-BELLAN (CNRS - CEA Saclay)

Amphithéâtre Léon Motchane (IHES)

Amphithéâtre Léon Motchane


Le Bois-Marie 35, route de Chartres 91440 Bures-sur-Yvette
Alternative Splicing is an important source of variety in the process of protein expression. It is deregulated in human diseases including cancer. The precise mechanism through which a splicing variant is selected for expression is not known at present. Here, we demonstrate that alternative splicing involves the RNA interference protein machinery, previously discovered as important for gene regulation at a distinct step, i. e. at the translational level.