When slicing meets splicing

par Prof. Annick HAREL-BELLAN (CNRS - CEA Saclay)

vendredi 18 janv. 2013, 11:00 → 12:00 Europe/Paris

Amphithéâtre Léon Motchane (IHES)

Alternative Splicing is an important source of variety in the process of protein expression. It is deregulated in human diseases including cancer. The precise mechanism through which a splicing variant is selected for expression is not known at present. Here, we demonstrate that alternative splicing involves the RNA interference protein machinery, previously discovered as important for gene regulation at a distinct step, i. e. at the translational level.