The seminar will take place on Zoom at the following link: https://univ-cotedazur.zoom.us/j/5698369814Short URLNone
Title:
Mechanics-driven long range communication between cells
Abstract :
Mechanics-driven communication between cells is essential for processes like angiogenesis, yet its integration into computational models remains limited. We developed a hybrid continuous-discrete model to study how mechanical cues influence cell migration on elastic fiber matrices. Refinement of the model requires to represent cells as mechanosensitive networks, where adhesions and filopodia interact dynamically with the substrate. Simulations demonstrate that cells adapt their migration patterns based on substrate properties, reproducing experimentally observed behaviors such as persistent random walks and migration bias on anisotropic substrates. This work provides a mechanistic framework to explore how mechanical signals mediate long-range communication between cells, offering insights into tissue morphogenesis and collective cell dynamics.