The Tracy-Widom distribution, defined via the Fredholm determinant associated with the Airy kernel, has emerged as a universal distribution in various contexts, including statistical mechanics, stochastic processes, and related fields. The aim of this presentation is to introduce our recent approach in establishing a novel deformation of the Tracy-Widom distribution, linked to a broad class of Schrödinger-type ODE systems. I will elucidate the underlying mathematical structures of this method, including a nonlinear integro-differential equation as a deformation of the Painlevé II equation, the hierarchical Poisson structure, and its connection to the isomonodromic system. This is based on a joint-work with Xavier Navand, https://arxiv.org/abs/2408.06888