Measure of stability violation as probable mathematical marker for pre-pathological unsustainability of human metabolism at health-to-disease transitions

par Prof. Victoria NIKIFOROVA (IPP-RAS Moscow, MPI-MP Potsdam & IHES)

mardi 29 mars 2016, 11:00 → 12:00 Europe/Paris

Amphithéâtre Léon Motchane (IHES)

Living organism, considered as a complex biological system, sustains its functionality through interconnected molecular transformations denoted as metabolism. Modern biomedical technologies allow simultaneous measurement of near all (small) organic molecules in a microsample of a biofluid such as blood. For the analysis of system viability, a complete set of metabolites from blood – blood metabolome – is of a prime resolution power, because i) metabolites are the final entities of the body's life-sustaining functionality in the line gene → proteine → metabolite, and as such totalize in their concentrations the organismal processes at all organisational levels, and ii) circulating blood, serving as a transmitter for all metabolites, is a whole-body metabolic information integrator. We collect blood metabolome data in a format of a comprehensive set of concentrational curves on a time trajectory health-to-disease, and explore the applicability of mathematical approaches for stability measurement to these big biodata sets in search for markers of pre-pathological metabolism sustainability violations.