Mechanistic links between cellular trade-offs, gene expression, and growth

par Prof. Peter Swain (Center for synthetic and systems biology, University of Edinburgh)

vendredi 13 mai 2016, 14:00 → 15:00 Europe/Paris

Salle de séminaire 4ième étage (Bâtiment CEI-2 Antenne Inria Lyon)

Intracellular processes rarely work in isolation but continually interact with the rest of the cell. The mechanisms driving such global regulation, however, are not well understood. Here I will consider three trade-offs that, because of limitations in levels of cellular energy, free ribosomes, and proteins, are faced by all living cells and construct a mechanistic model that comprises these trade-offs. I will show that the model recovers Monod's law for the growth of microbes and two other empirical relationships connecting growth rate to the mass fraction of ribosomes. Further, I will discuss growth-related effects in dosage compensation by paralogs, host-circuit interactions in synthetic biology, and simple models of evolution.