Séminaire Modélisation mathématique pour la biologie et la santé ICJ

A mathematical model for the onset and progression of Alzheimer's disease

par Dr Michiel Bertsch (University of Rome Tor Vergata)

Salle de séminaire 4ième étage (Bâtiment CEI-2 Antenne Inria Lyon)

Salle de séminaire 4ième étage

Bâtiment CEI-2 Antenne Inria Lyon

INRIA- antenne Lyon- La Doua Batiment CEI-2 56 Boulevard Niels Bohr 6960 Villeurbanne cedex France
We discuss a mathematical model for the onset and progression of Alzheimer’s disease based on transport and diffusion equations. We treat brain neurons as a continuous medium and structure them by their degree of malfunctioning. Two different mechanisms are assumed to be relevant for the temporal evolution of the disease: i) diffusion and agglomeration of soluble polymers of beta-amyloid, produced by damaged neurons; and ii) neuron-to-neuron prion-like transmission. We model these two processes by a system of Smoluchowski equations for the amyloid concentration, coupled to a kinetic-type transport equation for the distribution function of the degree of malfunctioning of neurons. The second equation contains an integral term describing the random onset of the disease as a jump process localized in particularly sensitive areas of the brain. Our numerical simulations are in good qualitative agreement with clinical images of the disease distribution in the brain which vary from early to advanced stages (joint work with B. Franchi, N. Marcello, M.C. Tesi and A. Tosin).
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