A Diagram Representation of Interactions of Modules in Biological Molecules

par Prof. Sigeo IHARA (Research Center for Advanced Science and Technology & the Institute of Biology and Mathematics for Dynamics Cellular Processes (iBMath), University of Tokyo)

lundi 14 sept. 2015, 11:00 → 12:00 Europe/Paris

Amphithéâtre Léon Motchane (IHES)

After overviewing the representation of biological molecules, I introduce the representation of interactions between modules in the proteins with the SO(3) rotation of the peptide unit introduced by Penner et al.. Using protein data in PDB, I will show our representation with the SO(3) rotation is useful in characterizing the structure and its change due to the mutation or the native dynamical change with time. I also discuss some possible potential extensions of our approach to the chromatin structure.