Switching between two modes of cell life: Growth & Conservation ition

par Nava Segev (University of Illinois, Chicago)

jeudi 16 avr. 2026, 11:30 → 13:00 Europe/Paris

Bâtiment Alix et Marwan Lahoud (IHES)

Depending on nutrient availability, cells switch between two different modes: growth, which requires secretion, and conservation, which requires autophagy, a cellular recycling pathway. The mechanisms underlying the switch between these two modes are not clear. We propose that the evolutionary-conserved Ypt1/Rab1 GTPase, which is essential for the beginning of secretion and macro-autophagy pathways from yeast to human, coordinate this switch by functioning in two different “GTPase Modules” that include “pathway-specific” upstream activators and downstream effectors.