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SUMMARY:Diane Peurichard\, "Mathematical modeling of tissue morphogenesis 
 and regeneration"
DTSTART:20250606T090000Z
DTEND:20250606T100000Z
DTSTAMP:20260316T173400Z
UID:indico-event-14394@indico.math.cnrs.fr
DESCRIPTION:Speakers: Diane Peurichard (INRIA)\n\nIn this talk\, we invest
 igate the mechanisms by which organs acquire their functional structure\, 
 realize its maintenance over time and rebuild their architecture after inj
 ury. We do this by means of two-dimensional Individual Based Models (IBM) 
 of interacting cells and extra-cellular-matrix fiber elements.  The mechan
 ical model first shows that the emergence of organized structures could be
  explained by simple mechanical interactions between the cells and the col
 lagen fibers. Our assumption is that the fiber network resists the pressur
 e induced by the growing cells and forces them to regroup into clusters. R
 eciprocally\, cell clusters force the fibers to merge into a well-organize
 d network. When applied to adipose tissues\, the model produces structures
  that compare quantitatively well to the experimental observations and see
 ms to indicate that cell clusters could spontaneously emerge as a result o
 f simple mechanical interactions between cells and fibers and surprisingly
 \, vasculature is not directly needed for these structures to emerge. In t
 he second part of the talk\, we extend this model to account for mechanism
 s of tissue repair after injury\, and use it to explore the mechanisms res
 ponsible for adipose tissue regeneration. The model successfully generates
  regeneration or scar formation as functions of few key parameters\, and s
 eems to indicate that the fate of injury outcome could be mainly due to ex
 tra-cellular (ECM) matrix rigidity. Altogether\, these studies point to th
 e essential role of mechanics in tissue structuring and regeneration\, and
  bring a comprehensive view on the role of ECM crosslinking on tissue arch
 itecture emergence and reconstruction. \n\nhttps://indico.math.cnrs.fr/eve
 nt/14394/
LOCATION:Salle de réunion\, 5ème étage (Fizeau)
URL:https://indico.math.cnrs.fr/event/14394/
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