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SUMMARY:Multiscale Modeling of Neuroblastoma Organoids: From Gene Regulato
 ry Networks to Spatial Dynamics
DTSTART:20250327T123000Z
DTEND:20250327T133000Z
DTSTAMP:20260505T041900Z
UID:indico-event-13903@indico.math.cnrs.fr
DESCRIPTION:Speakers: Thi Nhu Thao Nguyen (Univ. Paris Cité)\n\nIn this t
 alk\, I will present a multiscale model of neuroblastoma organoids\, which
  are child tumors of the sympathetic nervous system derived from the primi
 tive neural crest cells. At the molecular level\, we implemented a simple 
 gene regulatory network (GRN) in the form of a toggle switch between two g
 enes\, one driving the stemness and the other characterizing a differentia
 ted phenotype. This GRN has been encoded as a biologically realistic mecha
 nistic model driven by transcriptional burst for gene expression. Cellular
  decision-making (proliferation\, death\, differentiation) is driven by pr
 otein concentrations produced by the GRN. To check the realism of the 3D s
 tructures obtained\, we compared the simulation results\, both visually an
 d using appropriate statistics\, with immunohistochemistry (IHC) images\, 
 using quantitative measurements of spatial distributions.\n\nhttps://indic
 o.math.cnrs.fr/event/13903/
LOCATION:E2290 (Tours)
URL:https://indico.math.cnrs.fr/event/13903/
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