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SUMMARY:Deciphering Circulating Tumor Cells binding in a microfluidics sys
 tem thanks to a parameterized mathematical model
DTSTART:20250513T130000Z
DTEND:20250513T140000Z
DTSTAMP:20260507T172900Z
UID:indico-event-13466@indico.math.cnrs.fr
DESCRIPTION:Speakers: Christèle Etchegaray\n\nCancer metastasis is the le
 ading cause of cancer-related deaths\, and involves tumor cells disseminat
 ing in the body through blood circulation. These so-called Circulating Tum
 or Cells (CTC) may then decelerate and escape the flow thanks to their adh
 esion with the vessel wall. However\, the interplay between hydrodynamics 
 forces and cell dynamics remains poorly understood. In this talk\, we are
  interested in the dynamics of Circulating Tumor Cells in a microfluidic d
 evice that decelerate thanks to their adhesion with an endothelial monolay
 er. The data extracted from experimental movies consist in cell trajectori
 es. We developed a mathematical modeling framework coupling a Poiseuille f
 low and an Ordinary Differential Equation for the cell dynamics. A two-ste
 p model calibration using mixed-effects allowed to reconstruct the fluid v
 elocity before fitting the adhesion activity to individual trajectories. T
 he selected model then provided further insights on the interplay between 
 fluid velocity and cells adhesion repertoire. It paves the way for a digit
 al twin of flowing cells.\n\nhttps://indico.math.cnrs.fr/event/13466/
LOCATION:Fokko du Cloux (Bâtiment Braconnier\, La Doua)
URL:https://indico.math.cnrs.fr/event/13466/
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