Speaker: John Fricks from Arizona State University
Abstract: Molecular motors, specifically kinesin and dynein, transport cargos, including vesicles and ion channels, along microtubules in neurons to where they are needed. Such transport is vital to the well-functioning of neurons, and the breakdown in such transport function has been implicated in a number of neurodegenerative diseases. Since their discovery several decades ago, a variety of nano-scale experimental methods have been developed to better understand the function of transport-based molecular motors. In this talk, it will be shown how stochastic modeling techniques, such as functional central limit theorems, and statistical inference techniques for time series, such as particle filtering and EM algorithms, can be combined to better understand these experiments and give insight into the mechanisms behind motor-based intra-cellular transport.
Calendar subscription link for the complete seminar series:
https://indico.math.cnrs.fr/category/711/events.ics
Program of the Biostatistics seminars:
https://indico.math.cnrs.fr/category/711/
Subscribe to the seminar mailing list:
https://diff.u-bordeaux.fr/sympa/subscribe/seminaire.biostat.bph
Former e-seminars on our YouTube channel (mostly in French): https://www.youtube.com/channel/UCURp-hEQL7k23UzGfqgEurA/videos
Biostatistics seminar series from the Department of Public Health from the University of Bordeaux and the Bordeaux Population Health UMR 1219 research center
Boris Hejblum