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SUMMARY:The Expensive Germline and the Disposable Soma: exploring the co-e
 volution of life history and deleterious mutation rate
DTSTART:20231215T100000Z
DTEND:20231215T110000Z
DTSTAMP:20260423T064700Z
UID:indico-event-10005@indico.math.cnrs.fr
DESCRIPTION:Speakers: Piret Avila (Institute for Advanced Study in Toulous
 e)\n\nThe cost of germline maintenance and repair gives rise to a trade-of
 f between immutability (lowering deleterious mutation rates) and life-hist
 ory functions. Life-histories and the mutation rate therefore co-evolve\, 
 but this joint evolutionary process is not well understood. I present a ma
 thematical model to analyse the long-term evolution of traits affecting li
 fe-histories and deleterious mutation rate. I show that evolutionary stabl
 e life-histories and mutation rates can be  characterised using the basic
  reproductive number of the least-loaded class (expected lifetime producti
 on of  offspring without deleterious mutations born to individuals with t
 he smallest number of deleterious mutations). We further analyse two speci
 fic biological scenarios: (i) co-evolution between reproductive effort and
  mutation rate and (ii) co-evolution between age at maturity and mutatio
 n rate. These two scenarios suggest two results. First\, the trade-off bet
 ween immutability vs life-history functions depends strongly on environmen
 tal conditions and baseline mutation rate. For example\, low external mort
 ality and high radiation environment favour high investment into immutabil
 ity. Second\, the trade-offs between different life-history factors can be
  strongly affected by mutation rate co-evolution and higher baseline mutat
 ion rates  select for “faster life histories”: (i) higher investment 
 into fecundity at the expense of survival and (ii) earlier age of matura
 tion at smaller sizes. I will also discuss the implications of this model 
 on understanding evolution of ageing and I will give an overview of my f
 uture research agenda concerning the evolution of ageing.\n\nhttps://indi
 co.math.cnrs.fr/event/10005/
LOCATION:K. Johnson
URL:https://indico.math.cnrs.fr/event/10005/
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